Orphan Annie-eye Nuclei

The nucleus forms the central part of a cell which controls gene expression and mediates the replication of deoxyribonucleic acid (DNA) during cell cycle. Two main types of nuclei which we usually encounter are the open face (transcriptionally active cells), consisting of large areas of euchromatin and the closed faced nucleus (transcriptionally inactive cells-most of its genome is in inactive state) with heterochromatin areas. There are various other forms of nuclei which exhibit significant and interesting morphological features. Here, we would like to discuss a not so rare, but a unique entity–Orphan Annie-eye nuclei.